Psst--the thread is "actor/actress," not "film."
So I'll say Fay Wray in Woman in the Dark (1934).
Next: An utterly unredeemable villain.
Some days I am so plagued by envy and other sins I don't know whether to consult a psychiatrist or exorcist.
Kay Francis in Street of Women (1932)
The Balloonatic (1923)